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ARFGAP3 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q9NP61 |
| Reactivity | Rat, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 57 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ARFGAP3 |
| Epitope Specificity | 412-516/516 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm. Golgi apparatus membrane. Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment. |
| SIMILARITY | Contains 1 Arf-GAP domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | ARFGAP1 (ADP-ribosylation factor GTPase-activating protein 1), ARFGAP2 (ADP-ribosylation factor GTPase-activating protein 2) and ARFGAP3 (ADP-ribosylation factor GTPase-activating protein 3) are GTPase-activating proteins (GAP) that are associated with the Golgi apparatus and interact with ADP-ribosylation factor 1 (ARF). These proteins promote hydrolysis of ARF-bound GTP and are required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of ARFGAP1, ARFGAP2 and ARFGAP3 is stimulated by phosphoinosides and inhibited by phosphatidylcholine. The genes encoding ARFGAP1, ARFGAP2 and ARFGAP3 map to human chromosomes 20q13.33, 11p11.2 and 22q13.2, respectively. |
| Gene ID | 26286 |
|---|---|
| Other Names | ADP-ribosylation factor GTPase-activating protein 3, ARF GAP 3, ARFGAP3, ARFGAP1 |
| Target/Specificity | Widely expressed. Highest expression in endocrine glands (pancreas, pituitary gland, salivary gland, and prostate) and testis with a much higher expression in the testis than in the ovary. |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | ARFGAP3 |
|---|---|
| Synonyms | ARFGAP1 |
| Function | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. |
| Cellular Location | Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment |
| Tissue Location | Widely expressed. Highest expression in endocrine glands (pancreas, pituitary gland, salivary gland, and prostate) and testis with a much higher expression in the testis than in the ovary |
Research Areas
Citations (0)
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Application Protocols
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$ 385.00
Cat# AP54870
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